Jie Shen

Associate Professor (PI),School of Artificial Intelligence, Hangzhou Dianzi Univ., China2013 – Present

Dedicated in the understanding of aging mechanism using Drosophila as the model organism

EDUCATION

Ph.D., Molecular and Computational Biology Program, Univ. of Southern California, US           2009                                                                      

Bachelor of Science, Biotechnology, Zhejiang Univ. (Yuquan Campus), China                            2002

SELECTED PUBLICATIONS

 1.Shen, J., B. Liang, D. Zhang, Y. Li, H. Tang, L. Zhong, and Y. Xu, Effects of PET microplastics on the physiology of Drosophila. Chemosphere, 2021. 283: p. 131289.（1st author& corresponding author, IF=7.086）

2.Li, H., B. Liang, Y. Cao, Y. Xu, J. Chen, Y. Yao, J. Shen, and D. Yao, Effects of Chinese herbal medicines on lifespan in Drosophila. Exp Gerontol, 2021. 154: p. 111514.（corresponding author, IF=3.376）

3.Shen, J., P. Yang, X. Luo, H. Li, Y. Xu, J. Shan, Z. Yang, and B. Liang, Green light extends Drosophila longevity. Exp Gerontol, 2021. 147: p. 111268.（1st author& corresponding author, IF=3.376）

4.Shen, J., P. Yang, X. Zhu, Y. Gu, J. Huang, and M. Li, CO2 anesthesia on Drosophila survival in aging research. Arch Insect Biochem Physiol, 2020. 103(1): p. e21639.（1st author& corresponding author）

5.Shen, J., J. Shan, X. Zhu, P. Yang, D. Zhang, B. Liang, M. Li, X. Zang, and Z. Dai, Sex specific effects of capsaicin on longevity regulation. Exp Gerontol, 2020. 130: p. 110788.（1st author& corresponding author）

6.Shen, J., J. Shan, X. Zhu, Y. Xu, and M. Li, Effect of Chinese Herbal Tea on Health Tested on Drosophila Model. Plant Foods Hum Nutr, 2020.（1st author& corresponding author）

7.Landis, G.N., D.V. Doherty, C.A. Yen, L. Wang, Y. Fan, I. Wang, J. Vroegop, T. Wang, J. Wu, P. Patel, S. Lee, M. Abdelmesieh, J. Shen, D.E.L. Promislow, S.P. Curran, and J. Tower, Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide and Mifepristone/RU486 in Female Drosophila melanogaster. J Gerontol A Biol Sci Med Sci, 2020.（TOP，IF=5.957）

8.Shen, J., X. Zhu, Y. Gu, C. Zhang, J. Huang, and Q. Xiao, Toxic Effect of Visible Light on Drosophila Life Span Depending on Diet Protein Content. J Gerontol A Biol Sci Med Sci, 2019. 74(2): p. 163-167.（1st author& corresponding author，TOP，IF=5.957）

 9.Shen, J. and J. Tower, Effects of light on aging and longevity. Ageing Res Rev, 2019. 53: p. 100913.(1st author& corresponding author，TOP，IF=10.39)

10.Shen, J., Programmed Cell Death, in Encyclopedia of Gerontology and Population Aging, D. Gu and M.E. Dupre, Editors. 2019, Springer International Publishing: Cham. p. 1-6.（1st author& corresponding author）

11.Tower, J., G.N. Landis, J. Shen, R. Choi, Y. Fan, D. Lee, and J. Song, Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide. Biogerontology, 2017. 18(3): p. 413-427.

 12.Shen, J., G.N. Landis, and J. Tower, Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration. J Gerontol A Biol Sci Med Sci, 2017. 72(1): p. 44-53.（1st author，TOP，IF=5.957）

 13.Shen, J. and J. Tower, Aging, MnSOD, and hormesis mechanisms converge on liver mUPR. Cell Cycle, 2013. 12(20): p. 3237-8.（1st author& corresponding author）

 14.Landis, G., J. Shen, and J. Tower, Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY), 2012. 4(11): p. 768-89.

 15.Shen, J. and J. Tower, Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. Exp Gerontol, 2010. 45(2): p. 97-105.（1st author）

 16.Waskar, M., G.N. Landis, J. Shen, C. Curtis, K. Tozer, D. Abdueva, D. Skvortsov, S. Tavare, and J. Tower, Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY), 2009. 1(11): p. 903-36.

 17.Shen, J. and J. Tower, Programmed cell death and apoptosis in aging and life span regulation. Discov Med, 2009. 8(43): p. 223-6.（1st author）

 18.Shen, J., D. Ford, G.N. Landis, and J. Tower, Identifying sexual differentiation genes that affect Drosophila life span. BMC Geriatr, 2009. 9: p. 56.（1st author）

 19.Shen, J., C. Curtis, S. Tavare, and J. Tower, A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Aging (Albany NY), 2009. 1(2): p. 191-211.（1st author）

Authorized invention patent

1. A rapid gene screening method that can simultaneously detect four contaminating bacteria in fruit juice drinks ZL201510808866.X

2. Simultaneous identification of four types of contaminated yeasts in beer brewing, a rapid genetic screening method ZL201510809739.1

3. Simultaneously identify the rapid genetic screening method of a variety of heat-resistant bacteria in fruit juice beverages ZL201510809173.2

4. Primer composition, kit and method of use for detecting the expression level of key genes of autophagy in Drosophila melanogaster ZL201710010283.1

5. Primer composition, kit and method of use for detecting the expression level of key genes in circadian rhythm regulation in Drosophila melanogaster ZL201710010993.4

6. Primer composition, kit and method of use for detection of insulin-like peptide ILP series gene expression level in Drosophila melanogaster ZL201710010284.6

Academic, EDITORIAL AND REVIEW ACTIVITIES

1. Member of the Committee of the Anti-Aging Branch of the Chinese Society of Gerontology and Geriatrics

2. Young member of the Professional Committee of Zhejiang Society of Microbiology

3. Member of the Thyroid Disease Professional Committee of Zhejiang Academy of Mathematical Medicine

4. Hangzhou Science Popularization Expert

5. Editorial board member of "Frontiers in Genetics of Aging" and "Biochemistry and Molecular Biology Education"

6. Reviewers of multiple international journals