魏小云

     魏小云，博士，副研究员。2020年7月至今任教于杭州电子科技大学自动化（人工智能）学院。主要从事组织/器官生物3D打印、微纳生物制造及肿瘤体外模型精准构建等领域的研究。主持国自然青年基金、浙江省青年基金项目，参与国家重点研发计划、重大仪器专项等项目，作为第一作者/通讯作者发表SCI论文20余篇。

       课题组聚焦生物3D打印、微纳生物制造等医工交叉的前沿领域，基于此开发生物医学应用平台。课题组将给每位加入的同学提供一个相对宽松而又自由的科研氛围，鼓励进行科学前沿探索，欢迎感兴趣的同学联系！

2015.09—2020.06，武汉大学， 物理科学与技术学院， 硕博 

2011.09—2015.06，湖北大学， 材料科学与工程学院， 学士

2020.07—至今，杭州电子科技大学，自动化（人工智能）学院

• Gels期刊特刊客座编辑 Gels | Special Issue : 3D Bioprinting Hydrogels for Tissue Engineering and Regenerative Medicine

• Biomaterials, Chemical engineering journal, Materials today Bio等期刊审稿人
  

生物3D打印、微流控芯片、肿瘤类器官

通识选修课《工程生物学》《现代生命科学导论》

专业选修课《生物技术概论》

• 国自然青年科学基金项目，时空3D打印构建动态基质微环境PDAC类器官及用药选择系统，

  2024.01-2026.12，主持

• 省自然科学基金探索青年，双组分凝胶微珠打印空间特征化胰腺癌模型及药物筛选研究，

  2023.01-2025.12，主持

• 国家重点研发计划项目，基于干细胞时空迭代3D打印的复杂组织制造与功能重建研究，

  2022.12-2027.11，参与

教师一作论文：

1. Xiaoyun Wei,* Xingrun Lan, Yiqian Pan, Ling Wang, Keke Chen,* Mingen Xu.* Microarray chip to fabricate 3D PDAC heterospheroids with architectural organization towards tumor invasion and chemoresistance study. Microsystems & Nanoengineering 2026, 12, 310.

2. Xiaoyun Wei,* Yiwen Wu, Keke Chen, Ling Wang,* Mingen Xu.* Embedded bioprinting multicellular spheroids modeling pancreatic cancer bioarchitecture towards advanced drug therapy. Journal of Materials Chemistry B 2024, 12, 1788-1797.

3. Xiaoyun Wei,* Beisi Huang, Keke Chen, Zicheng Fan, Ling Wang, Mingen Xu.* Dot extrusion bioprinting of spatially controlled heterogenous tumor models. Materials & Design 2022, 223, 111152.

4. Xiaoyun Wei, Keke Chen, Shishang Guo,* Wei Liu,* Xing-Zhong Zhao.* Emerging Microfluidic Technologies for the Detection of Circulating Tumor Cells and Fetal Nucleated Red Blood Cells. ACS Applied Bio Materials 2021, 4, 1140-1155.

5. Xiaoyun Wei, Keke Chen, Bo Cai, Lang Rao, Zixiang Wang, Yue Sun, Mingxia Yu, Wei Liu, Shishang Guo,* Xing-Zhong Zhao.* An Acoustic Droplet-Induced Enzyme Responsive Platform for the Capture and On-Demand Release of Single Circulating Tumor Cells. ACS Applied Materials & Interfaces 2019, 11, 44, 41118-41126.

6. Xiaoyun Wei, Bo Cai, Keke Chen, et al., Enhanced isolation and release of fetal nucleated red blood cells using multifunctional nanoparticle-based microfluidic device for non-invasive prenatal diagnostics. Sensors and Actuators B: Chemical 2019, 281, 131-138.

   
   

   
   

学生一作论文：

1. Chenyang Han, Xiaoyun Wei,* Xingrun Lan, Ling Wang, Keke Chen,* Mingen Xu.*Fabrication of Hepatic Spheroid Microarray Chip with Biomimetic Microarchitecture for Drug Hepatotoxic Evaluation. Advanced Healthcare Materials 2026,15, e03476.

2. Xingrun Lan, Keke Chen,* Xiaoyun Wei.* Bioengineering 3D Pancreatic Cancer Models with Fibrotic Stroma for In Vitro Cancer Modeling. Micromachines 2025, 16, 1140.

3. Fang Chen, Xiaoyun Wei,* Keke Chen, Ling Wang, Mingen Xu.* Massive fabrication of functional hepatic cancer spheroids by micropatterned GelMA hydrogel chip for drug screening. Colloids and Surfaces B: Biointerfaces 2024, 244, 114171.

4. Zicheng Fan, Xiaoyun Wei,* Keke Chen, Ling Wang,* Mingen Xu.*3D Bioprinting of an Endothelialized Liver Lobule-like Construct as a Tumor-Scale Drug Screening Platform. Micromachines 2023, 14, 878.

5. Beisi Huang, Xiaoyun Wei,* Keke Chen, Ling Wang,* Mingen Xu.* Bioprinting of Hydrogel Beads to Engineer Pancreatic Tumor-Stroma Microtissues for Drug Screening. International Journal of Bioprinting 2023, 9(3), 676.

魏小云，徐铭恩，欧阳杨，一种时空3D打印肿瘤微环境类器官的方法，ZL202411989221.6

徐铭恩，陈柯坷，魏小云，王玲，三维成型方法及系统，ZL202110935366.8

国世上，陈柯坷，魏小云，一种声表面波液滴激发装置及定点释放肿瘤单细胞的方法，ZL201910351768.6