严明 副教授

严明，工学博士，现为杭州电子科技大学自动化学院教师，副教授，主要研究方向为生理系统仿真建模及生物医学数据智能处理等。主持国家自然科学基金青年基金项目一项，浙江省自然科学基金3项；参与多项国家自然科学基金、浙江省自然科学基金及横向课题研究；近年来在国内外高水平杂志上发表多篇文章，其中SCI收录30余篇。

1.2022/01至今，杭州电子科技大学，自动化学院，副教授

2.2018/08-2019/08，美国哈佛医学院，布莱根与妇女医院，组织工程及再生医学实验室，访问学者，导师：Myron Spector教授

3.2011/06-2021/12，杭州电子科技大学，自动化学院，讲师

本科生课程：

一、专业课

1.生物统计学

2.数据库原理及应用

3.虚拟仪器技术

二、通识选修课

1.舌尖上的人工智能

2.现代生命科学导论

主持项目：

1.国家自然科学基金，PERK-eIF2α介导的内质网应激-自噬通路在正畸牙移动压力区骨细胞损伤中的作用研究  

2.浙江省自然科学基金，基于三维打印技术和拟细胞外基质水凝胶材料构建3D仿生肺及其在大气颗粒物肺损伤中的应用研究

3.浙江省自然科学基金，基于三维打印技术和拟细胞外基质水凝胶材料构建3D肿瘤模型及其在量子点追踪肿瘤迁移过程的应用研究

4.浙江省自然科学基金，基于深度学习的膀胱癌单细胞代谢标志物鉴定技术研究

近期参与项目

1. 浙江省尖兵领雁研发攻关计项目, 生命科学分析仪器与试剂研发-单细胞代谢标志物分析仪与试剂研发

2. 浙江省自然科学基金, 基于三维纸基电化学的 SARS-CoV-2中和抗体 POCT 定量检测技术研究

3. 浙江省自然科学基金, 基于深度学习的表面等离子体共振成像自动分析用于生物纳米单颗粒动态检测

4. 之江实验室开放课题基于智能计算的大豆空间代谢组关键代谢物鉴定技术 

基于三维打印技术的下颌骨缺损修复PLGA/β-TCP 复合支架制备

(1) 田程远，严明*，张云，刘珂舟，郭淼，孙永红，薛凌云，祝磊，徐莹，杭州市中心城区大气PM2.5暴露致大鼠肺部损伤作用研究。中国应用生理学杂志, 2018, 34(4):299-303.

(2) 严明*，张云，刘珂舟，孙永红。碲化镉量子点抑制人脐静脉内皮细胞存活并损伤线粒体，中国药理学与毒理学杂志, 2017, 31(6):574-580.

(3) 严明*，张云，刘珂舟，孙永红。碲化镉量子点对血管平滑肌细胞的损伤作用，中国药理学与毒理学杂志, 2017, 31(2):165-171.

(4) Yan ming*，Zhang yun#，Qin haiyan，Liu kezhou，Guo miao，Geyakun，Xu mingen，Sun yonghong，Zheng xiaoxiang，Cytotoxicity of CdTe quantum dots in human umbilical vein endothelial cells: the involvement of cellular uptake and induction of pro-apoptotic endoplasmic reticulum stress，International Journal of Nanomedicine, 2016, 11:529-542.

(5) Ming Yan，Yun Zhang，Kedi Xu，Tao Fu，Haiyan Qin，Xiaoxiang Zheng*，An in vitro study of vascular endothelial toxicity of CdTe quantum dots. Toxicology, 2011, 282(ne 3):94-103.

(6) Ming Yan, Kedi Xu, Xiaoxiang Zheng, et al. Enhanced cellular function of human vascular endothelial Cell on poly (ɛ-caprolactone)/gelatin coaxial-electrospun scaffold. Applied Mechanics & Materials, 2011, 138-139:900-906.

(7) 杨子键，黄君瑶，高烨飞，黄文吉，徐世磊，金晶晶，万烨东，严明，毛红娇，张云#。佛手苷内酯对磷酸三钙磨损颗粒诱导骨细胞损伤的影响及机制. 中国应用生理学杂志, 2020, 35(6):563-568.

(8) 丁惠洁，刘珂舟，杨珊珊，严明*。大鼠脑皮层血管栓塞和再生过程的实时动态记录方法。生理学报, 2019(4):581-587.

(9) 林琨，陈佳濠，方泽浩，叶铖龙，韩超杰，严明，方剑，张云*。原花青素对磷酸三钙磨损颗粒所致小鼠颅骨溶解的干预作用及其机制. 中国应用生理学杂志, 2019, 35(3):250-255.

(10)Wanting Niu, Ravikumar Rajjappa, Yunfei Ma, Meral S. Nadra, Ming Yan, Hu-Ping Hsu, Motoichi Kurisawa, Myron Spector. Effects of Extracorporeal Shockwaves on Bone Marrow Stimulation for Cartilage Repair in Gelatin Based Injectable Hydrogel. Orthopaedic Research Society Annual Meeting 2019, February 2nd-5th, Austin, Texas, USA.

(11) 张雨笛，严明，俞立虹，章思烨，诸葛建颖，郭健恒，丁樑，张云*。PI3K/Akt 信号通路在磷酸三钙磨损颗粒诱导小鼠颅骨溶解中的作用。中国运动医学杂志, 2017,36(3):212-217.

(12) Yun Zhang*, Ming Yan, Qingfeng Yu, et al. Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation. Biological & Pharmaceutical Bulletin, 2016, 39(12):2028-2035.

(13) Suming Lv, Yun Zhang*, Ming Yan, et al. Inhibition of osteolysis after local administration of osthole in a TCP particles-induced osteolysis model. International Orthopaedics, 2016, 40(7):1545-1552.

(14) Chaodan Pu, Junliang Ma, Haiyan Qin, Ming Yan et al. Doped Semiconductor-Nanocrystal Emitters with Optimal Photoluminescence Decay Dynamics in Microsecond to Millisecond Range: Synthesis and Applications. ACS Central Science, 2016, 2(1):32-39.(IF=7.939)

(15) Kezhou Liu, Ming Yan, Xiaoxiang Zheng, et al. The dynamic detection of NO during the ischemic postconditioning against global cerebral ischemia/reperfusion injury. Nitric Oxide Biology & Chemistry, 2014, 38(234):17-25. (IF=4.181)

(16) Mingxia Zheng, Yongliang Ge, Haiyu Li, Ming Yan et al. Bergapten prevents lipopolysaccharide mediated osteoclast formation, bone resorption and osteoclast survival. International Orthopaedics, 2014, 38(3):627-634.

(17) Yun Zhang*, Ming Yan, Aiyue Yu, et al. Inhibitory effects of beta-tricalciumphosphate wear particles on osteocytes via apoptotic response and Akt inactivation. Toxicology, 2012, 297(1-3):57-67. (IF=4.017)

(18) Kedi Xu, Yi Yang, Ming Yan, et al. Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells. Journal of Lipid Research, 2010, 51(9):2581-2590. (IF=6.115)

(19) Xiaoyu Liu, Lingqing Feng, Ming Yan, et al.. Changes in mitochondrial dynamics during amyloid β-induced PC12 cell apoptosis. Molecular & Cellular Biochemistry, 2010, 344(1-2):277-284. 17

(20) Xiaoyu Liu, Kedi Xu, Ming Yan, et al. Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress. Neurochemistry International, 2010, 57(5):588. (IF=3.601)

(21) Yiguo Sun, Tongle Deng, Na Lu, Ming Yan, et al. B-type natriuretic peptide protect cardiomyocytes at reperfusion via mitochondrial calcium uniporter. Biomedicine&Pharmacotherapy, 2010, 64(3):170-176.

(22) Kedi Xu, Ming Yan, Yongping Wang, et al. Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway. Atherosclerosis, 2009, 207(1):123-130. (IF=4.522)

(23) Yiguo Sun, Yun Zhang, Ming Yan, et al. B-Type Natriuretic Peptide-Induced Cardioprotection against Reperfusion Is Associated with Attenuation of Mitochondrial Permeability Transition. Biological & Pharmaceutical Bulletin, 2009, 32(9):1545-1551.

(24) Huijuan Yang, Ling Gu, Le Zhang, Ming Yan et al. Involvement of hydrogen peroxide in the

manganese-induced myocytes mitochondrial membrane potential loss. Toxicology Methods, 2009, 19(1):66-72.

(25) Wei Yuan , Yun Zhang, Yakun Ge, Ming Yan et al. Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro. Planta Medica, 2008, 74(10):1259-1264.

(26) Yun Zhang, Le Zhang, Ming Yan, et al. Inhibition of phosphatidylinositol 3-kinase causes cell death in rat osteoblasts through inactivation of Akt. Biomedicine & pharmacotherapy, 2007, 61(5):277-284.

(27) Zhengwei Mao, Lie Ma, Yan Jiang, Ming Yan et al. The gene transfection efficiency of thermoresponsive N,N,N-trimethyl chitosan chloride-g-poly(N-isopropylacrylamide) copolymer. Biomaterials, 2007, 28(30):4488-4500. (IF=6.262)

(28) Tiannan Wang, Ming Yan, Jieyue Li, et al. The role of iNOS-derived NO in the antihypertrophic actions of B-type natriuretic peptide in neonatal rat cardiomyocytes. Molecular & Cellular Biochemistry, 2007, 302(1-2):169-177.

(29) Zhengwei Mao, Lie Ma , Yan Jiang, Ming Yan et al. N,N,N-Trimethylchitosan chloride as a gene vector: synthesis and application. Macromolecular Bioscience, 2007, 7(6):855-863. (IF=3.238)

(30)  Yun Zhang; Ming Yan M ; Shumeng Kuang; Yiqiang Lou; Shouqian Wu; Yurong Li; Zihan Wang; Hongjiao Mao ; Bisphenol A induces apoptosis and autophagy in murine osteocytes MLO-Y4: Involvement of ROS-mediated mTOR/ULK1 pathway, Ecotoxicology and Environmental Safety, 2022, 230

(31) Yun Zhang; Ming Yan M ; Weiyan Shan a; TaoZhang; Yunchen Shen; Ruirong Zhu; Jian Fang; Hongjiao Mao ; Bisphenol A induces pyroptotic cell death via ROS/NLRP3/Caspase-1 pathway in osteocytes MLO-Y4, Food and Chemical Toxicology, 2022, 159 

(32) Ming Yan M ; Yun Zhang; Wanting Niu; Kezhou Liu; Lingyun Xue; Kexin Zhou ; Reactive oxygen species‐mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force, Microscopy Research and Technique, 2023, 86(11): 1-13 

(33) Ping Xu; Yang Zhao; Lingyun Xue; Yian Liu; Ming Yan M ; Lei Zhu; Weng Lin; Shundi Hu; LuhongWen ; Fentanyl analogs classification via Siamese network and mass spectral library searching, Expert Systems with Applications, 2023, 217: 119534

主持项目：

1.国家自然科学基金，PERK-eIF2α介导的内质网应激-自噬通路在正畸牙移动压力区骨细胞损伤中的作用研究  

2.浙江省自然科学基金，基于三维打印技术和拟细胞外基质水凝胶材料构建3D仿生肺及其在大气颗粒物肺损伤中的应用研究

3.浙江省自然科学基金，基于三维打印技术和拟细胞外基质水凝胶材料构建3D肿瘤模型及其在量子点追踪肿瘤迁移过程的应用研究

4.浙江省自然科学基金，基于深度学习的膀胱癌单细胞代谢标志物鉴定技术研究

近期参与项目

1. 浙江省尖兵领雁研发攻关计项目, 生命科学分析仪器与试剂研发-单细胞代谢标志物分析仪与试剂研发

2. 浙江省自然科学基金, 基于三维纸基电化学的 SARS-CoV-2中和抗体 POCT 定量检测技术研究

3. 浙江省自然科学基金, 基于深度学习的表面等离子体共振成像自动分析用于生物纳米单颗粒动态检测

4. 之江实验室开放课题基于智能计算的大豆空间代谢组关键代谢物鉴定技术 

Kai Zhu,Margaux Duchamp,Julio Aleman,Wanting Niu,Abdulmonem Alshihri,Yu Shrike Zhang,Ming Yan. Frontiers in Biomaterials - Porous Scaffold Design for Tissue Engineering: State-of-the-art and Future.Bentham Science Publishers